SNPs associated with lung function decline

SNPs in the genes coding for respectively Multidrug Resistance-associated Protein 1, Glutamate Cysteine Ligase Catalytic Subunit and Superoxide Dismutase 3 are associated with lung function decline concludes M.Siedliński in his PhD-thesis.

Mateusz Siedliński conducted his research at the department of Epidemiology and Respiratory Diseases of the University Medical Center Groningen, the Netherlands. The SNPs he found to be associated with a steeper decline of lung function compromise the activity of proteins that are involved in neutralizing the harmful effects of free radicals e.g. in cigarette smoke.  Based on his data Siedliński estimates that the activity of these proteins are compromised due to the presence of SNPs, in approximately 20 percent of the population

Siedliński also showed that a daily dose of vitamin C equal to the Recommended Dietary Allowance dampens the harmful effect of free radicals.

Mateusz Siedliński defended his PhD-thesis successfully 28 October 2009 at the University of Groningen, the Netherlands and received a “cum laude” for his work.

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